Bateriophages, or
phages, have been
studied for over a
century and are
considered safe.1, 2
Phages are natural
predators of bacteria and
are highly selective in
their targeting. Once their
host target is eliminated,
phages naturally
biodegrade.2
Studies link acne-free
skin to the abundance of
C. acnes phages and the
presence of acne lesions
is associated with fewer
phages.3
The widespread adoption of antibiotics contributed to
the decline in interest and broad awareness of phages.
However, the rise of antibiotic resistance has contributed to
a resurgence in the therapeutic applications of phages.
Research continues to demonstrate a correlation between lower skin microbiome diversity and inflammatory skin conditions including acne, psoriasis, and atopic dermatitis. We welcome you to explore some of the published literature.
References: 1. Natarelli, N.; Gahoonia, N.; Sivamani, R.K. Bacteriophages and the Microbiome in Dermatology: The Role of the Phageome and a Potential Therapeutic Strategy. Int. J. Mol. Sci. 2023, 24, 2695. https://doi.org/ 10.3390/ijms24032695. 2. Ly-Chatain MH (2014) The factors affecting effectiveness of treatment in phages therapy. Front. Microbiol. 5:51. doi: 0.3389/fmicb.2014.00051. 3. Barnard, E. et al. The balance of metagenomic elements shapes the skin microbiome in acne and health. Sci. Rep. 6, 39491; doi: 10.1038/srep39491 (2016). 4. Golembo M, Puttagunta S, Rappo U, Weinstock E, Engelstein R, Gahali-Sass I, et al. Development of a topical bacteriophage gel targeting Cutibacterium acnes for acne prone skin and results of a phase 1 cosmetic randomized clinical trial. Skin Health Dis. 2022;2(2):e93. ttps://doi.org/10.102/ski2.93.
