Use Of Phages In Acne Is
A Natural, First-In-Class
Approach, Bridging Gaps
In Current Treatments

Bateriophages, or phages, have been studied for over a century and are considered safe. 1, 2

Phages are natural predators of bacteria and are highly selective in their targeting. Once their host target is eliminated, phages naturally biodegrade. 2

Studies link acne-free skin to the abundance of C. acnes phages and the presence of acne lesions is associated with fewer phages. 3

Phages bring the skin back to a healthy, acne-free
state, by controlling the overgrowth of C. acnes.
We call this ‘precise microbiome editing’.

PHYLA SUPPORTS A DIVERSE MICROBIOTA

A HISTORY OF PHAGES

The widespread adoption of antibiotics contributed to the decline in interest and broad awareness of phages.

However, the rise of antibiotic resistance has contributed to a resurgence in the therapeutic applications of phages.

Research continues to demonstrate a correlation between lower skin microbiome diversity and inflammatory skin conditions including acne, psoriasis, and atopic dermatitis. We welcome you to explore some of the published literature.

Many conventional acne treatments kill all bacteria, without the ability to target only the pathogenic C. acnes responsible for lesions, further disrupting the skin microbiota

Phages are a safe, natural treatment to change the microbiota for the better and without compromising the skin barrier. 4

References: 1. Natarelli, N.; Gahoonia, N.; Sivamani, R.K. Bacteriophages and the Microbiome in Dermatology: The Role of the Phageome and a Potential Therapeutic Strategy. Int. J. Mol. Sci. 2023, 24, 2695. https://doi.org/ 10.3390/ijms24032695. 2. Ly-Chatain MH (2014) The factors affecting effectiveness of treatment in phages therapy. Front. Microbiol. 5:51. doi: 0.3389/fmicb.2014.00051. 3. Barnard, E. et al. The balance of metagenomic elements shapes the skin microbiome in acne and health. Sci. Rep. 6, 39491; doi: 10.1038/srep39491 (2016). 4. Golembo M, Puttagunta S, Rappo U, Weinstock E, Engelstein R, Gahali-Sass I, et al. Development of a topical bacteriophage gel targeting Cutibacterium acnes for acne prone skin and results of a phase 1 cosmetic randomized clinical trial. Skin Health Dis. 2022;2(2):e93. ttps://doi.org/10.102/ski2.93.